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Id: | 13278
| Author: | Waters, M. F. R; Isa, Bakri Bin HJ; Rees, R. J. W; McDougall, A. C
| Title: | Experimental lepromatous leprosy in the white-handed gibbon (Hylobatus lar): successful inoculation with leprosy bacilli of human origin
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| Source: | s.l; s.n; dec. 1978. 7 p. ilus, tab.
| Abstract: | Leprosy bacilli of human origin were inoculated into a white-handed gibbon by the i.v. and i.p. routes, and also locally into ears, testis and around an ulnar nerve. The animal was observed closely during a period of nearly 15 years and did not exhibit any clinical evidence of cutaneous or neurological disease. At death, a wide range of tissues was taken for bacterial counts and histological examination, and a disseminated and progressive infection was demonstrated. Acid-fast bacilli were found in many sites; their morphological appearance, distribution in nerves, and pattern of multiplication in mouse foot-pads, and also the presence of anti-mycobacterial antibody in the serum and the absence of specific lymphocyte transformation were all in keeping with an infection by Mycobacterium leprae, at an early lepromatous infection in a primate. The findings are discussed in relation to the long incubation period of lepromatous leprosy and the difficulties of diagnosing the disease at an early stage in man.(AU).
| Descriptors: | ANTICORPOS ANTIBACTERIAS/anal MODELOS ANIMAIS DE DOENCAS MEMBRO POSTERIOR/patol HYLOBATES/anat HANSENIASE/imunol HANSENIASE/patol MYCOBACTERIUM LEPRAEMURIUM/isol MYCOBACTERIUM LEPRAEMURIUM/patogen PONGIDAE/anat NERVO ULNAR
| Limits: | ANIMAL MASCULINO
| Electronic Medium: | http://www.ilsl.br
| Location: | BR191.1; 00546/s |
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